Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9 |
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| Institution: | 1. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China;2. State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China;3. School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian 361102, China;4. State Key Laboratory for Physical Chemistry of Solid Surface, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China;5. Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Fujian, China;6. School of Biological Engineering, Jimei University, Xiamen, Fujian 361021, China;1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, Henan, PR China;2. College of Chemical Engineering, Hebei United University, Tangshan 063009, Hebei, PR China;3. College of Engineering Technology, Zhongzhou University, Zhengzhou 450052, Henan, PR China;1. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. Xinjiang Medical University, Urumqi 830054, PR China;4. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China;5. College of Chemistry and Life Science, Shenyang Normal University, Shenyang 110034, PR China;1. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;2. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 87317, Iran;3. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, (CSIR-CDRI), Sector 10, Jankipuram, Sitapur Road, Lucknow 226 031, India;2. Endocrinology Division, CSIR-Central Drug Research Institute, (CSIR-CDRI), Sector 10, Jankipuram, Sitapur Road, Lucknow 226 031, India;3. Department of Surgery, CSM Medical University, Lucknow, India;4. Academy of Scientific & Innovative Research (AcSIR), New Delhi, India |
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| Abstract: | Two new spirooxindole alkaloids spindomycins A (1) and B (2) were isolated from rhizosphere strain Streptomyces sp. xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B (2) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl. |
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| Keywords: | Spirooxindole alkaloids Rhizosphere |
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