Semisynthesis of salviandulin E analogues and their antitrypanosomal activity |
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Affiliation: | 1. Yokohama Research Laboratory, Hitachi, Ltd., Yokohama 244-0817, Japan;2. Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan |
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Abstract: | A series of analogues of salviandulin E, a rearranged neoclerodane diterpene originally isolated from Salvia leucantha (Lamiaceae), were prepared and their in vitro activity against Trypanosoma brucei brucei was evaluated with currently used therapeutic drugs as positive controls. One of the 19 compounds prepared and assayed in the present study, butanoyl 3,4-dihydrosalviandulin E analogue was found to be a possible candidate for an antitrypanosomal drug with fairly strong antitrypanosomal activity and lower cytotoxicity. |
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Keywords: | Semisynthesis Antitrypanosomal activity Neoclerodane diterpene Salviandulin E |
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