Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49 |
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| Institution: | 1. Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia;2. Department of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, D-97082 Würzburg, Germany;3. Department of Toxicology, University of Würzburg, Würzburg, Germany;4. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0NR, UK;1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA;2. Department of Pharmacology, University of Arizona, Tucson, AZ 85721, USA;1. College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea;2. Division of Life Sciences, Korea Polar Research Institute, KOPRI, Incheon 406-840, Republic of Korea;1. University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA;2. Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA;3. University of Pittsburgh Cancer Institute, Pittsburgh, PA 15260, USA;4. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA;5. Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA;6. Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA;1. Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China;2. Power China Huadong Engineering Corporation Limited, Hangzhou 311122, China;1. Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan;2. National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan;3. Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Takeda-4, Kofu 400-8511, Japan;4. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan |
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| Abstract: | Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain EG49 isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line. |
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| Keywords: | Sponges Actinomycetes Actinosporins Antioxidant |
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