Synthesis and radiolabeling of 111In-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging |
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Institution: | 1. Warren Alpert Medical School, Brown University, Providence, RI;2. Memorial Sloan Kettering Cancer Center, Department of Urology, New York, NY |
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Abstract: | The objective of this study was the development of a dual-modality imaging device, namely 111In-core-cross-linked polymeric micelle (CCPM)-octreotide, for neuroendocrine tumor detection, using near-infrared fluoroscopy (NIRF) and single photon emission computed tomography (SPECT). The tumor targeting ability of the 111In-labeled CCPM-octreotide was evaluated in a tumor mouse model. SPECT/CT, NIRF and gamma imaging results showed high tumor uptake of 111In-labeled CCPM-octreotide. In contrast, there was a much lower signal in the same mouse model injected with 111In-labeled CCPM. The high accumulation of 111In-labeled CCPM-octreotide in U87 tumor was reduced after co-injection with an excess amount of CCPM-octreotide. These results suggested CCPM-octreotide’s potential applications in tumor diagnosis, drug delivery and molecular imaging. |
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Keywords: | Dual-modality imaging Tumor detection Octreotide Near-infrared fluoroscopy Single photon emission computed tomography |
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