Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook |
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| Affiliation: | 1. Anhui University of Chinese Medicine, Hefei 230031, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;3. Yunnan Agricultural University, Kunming 650201, China;4. The Department of Neurology of the First Affiliated Hospital of Medical University of Anhui, China;1. College of Life Sciences, Nanjing Normal University, No. 1, Wenyuan Road, Nanjing, Jiangsu, China;2. College of Life Sciences, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang, Anhui, China;3. Nanjing Institute for Comprehensive Utilization of Wild Plants, No. 4, Jiangwangmiao Road, Nanjing, Jiangsu, China;1. Department of Agronomy, National Chung-Hsing University, Taichung 40227, Taiwan;2. The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 84001, Taiwan;3. Department of Biological Science and Technology, I-Shou University, Kaohsiung 84001, Taiwan;4. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan;5. Graduate Institute of Veterinary Pathobiology, National Chung-Hsing University, Taichung 40227, Taiwan;6. Department of Agronomy, Chiayi Agricultural Experiment Station, TARI, Chiayi 60044, Taiwan;7. Department of Animal Science and Biotechnology, Tunghai University, Taichung 40704, Taiwan;8. Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, Wufeng 41349, Taiwan;1. School of Medicine, Department of Pharmacology, China Medical University, Taichung, Taiwan;2. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan;3. Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan;1. School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, China;2. Department of Pharmacy, The First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, China;3. Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA |
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| Abstract: | The bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbibenzyls A–G (1–7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9,10-dihydrophenanthrene (8) and thirteen known compounds (9–21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 μM. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases. |
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| Keywords: | Bibenzyl dimer Fimbriadimerbibenzyl Cytotoxicity |
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