Synthesis,antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer |
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| Institution: | 1. School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi''an Jiaotong University, Xi''an, 710049, China;2. Key Laboratory of Thermo-Fluid Science and Engineering of MOE, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, 710049, China;3. Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi''an, 710049, China;4. Instrumental Analysis Center, Xi''an Jiaotong University, Xi''an, 710049, China;1. Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil;2. Laboratory of Phytochemistry and Medicinal Chemistry, Department of Pharmacy, Alfenas Federal University, Alfenas, Minas Gerais, Brazil;3. Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil;4. Laboratory of Organic Chemistry, Department of Chemistry, Viçosa Federal University, Viçosa, Minas Gerais, Brazil;1. Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, South Korea;2. Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan;3. Department of Anatomy, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, South Korea;4. College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae, Gyeongnam 50834, South Korea;1. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand |
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| Abstract: | Chronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I–VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I–III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV–VIII were identified as new, broad-spectrum UVA filters while II–III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer. |
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| Keywords: | Sunscreens Photoprotection Antioxidant UV radiation UV filters Avobenzone Octyl methoxycinnamate Molecular hybridization |
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