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Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR
Affiliation:1. Department of Bioengineering and Therapeutic Sciences and California Institute for Quantitative Biology, University of California, San Francisco, San Francisco, CA 94158, USA;2. Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Stanford, CA 94025, USA;3. Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA;4. Department of Biochemistry and Chemistry, Brandeis University, Waltham, MA 02454, USA;5. Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02139, USA;6. Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA
Abstract:
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