One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents |
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| Affiliation: | 1. Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, India;2. Department of Biochemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, India;2. Concordia Centre for Composites (CONCOM), Department of Mechanical & Industrial engineering, Concordia University, Montreal H3G 1M8, Canada;3. Département de Génie Mécanique, École Polytechnique de Montréal, C.P. 6079, Succ. Centre-ville, Montréal H3C 3A7, Canada;1. P.G and Research Department of Physics, National College, Tiruchirappalli 620001, India;2. P.G and Research Department of Physics, H.H. The Rajah’s College, Pudukkottai 622001, India;3. Department of Physics, A.A. Govt. Arts College, Musiri 621211, India;1. National Research Centre, Department of Photochemistry, El Behoose Street, PO Box 12622, Cairo, Dokki, Egypt;2. School of Engineering and Science, Centre for Nano and Functional Materials (NanoFun), Jacobs University, 28759 Bremen, Germany;1. Laboratori de Neurofarmacologia, IUNICS, Universitat de les Illes Balears (UIB), IdISBa, Palma de Mallorca, Spain;2. Redes Temáticas de Investigación Cooperativa en Salud–Red de Trastornos Adictivos (RETICS-RTA), ISCIII, Madrid, Spain;3. Centre Universitaire Romand de Médecine Légale, Genève, Switzerland;1. MRDL, PG and Research Department of Physics, Pachaiyappa’s College, Chennai, 600 030, Tamil Nadu, India;2. PG and Research Department of Physics, Arignar Anna Government Arts College, Cheyyar, Thiruvannamalai District, 604 407, Tamil Nadu, India;3. Research and Development Centre, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India;4. Department of Physics, The New College, Chennai, 600 014, Tamil Nadu, India;5. Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram, 608 002, Tamil Nadu, India |
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| Abstract: | A one-pot, three-component, microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one (4a–n) was carried out by using N,N-dimethylformamide as a solvent with high product yield. Among these synthesized compounds (4f, 4g, 4l and 4m) were found to be a broad spectrum molecule active against all bacterial and fungus strains tested, except fungus Aspergillus niger. Amongst the compounds (4g, 4l and 4m) were found to be more potent than respective standard drugs used in the experiment against Candida albicans, Staphylococcus aureus and Aspergillus flavus, respectively. All synthesized compounds were also tested for their cytotoxic activity against HeLa and MCF-7 cell lines by the sulforhodamine B (SRB) assay. This study shows that all compounds were non-cytotoxic in nature, and confirmed their antimicrobial specificity apart from any general cytotoxicity. |
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| Keywords: | Thiazolidin-4-one Microwave-assisted synthesis 2-Amino-5-chlorophenol Antimicrobial Cytotoxicity |
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