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Coumarin hybrids as novel therapeutic agents
Institution:1. Department of Chemistry, Yuvaraja''s College, University of Mysore, Mysuru, India 570005;2. Department of Studies in Physics, University of Mysore, Manasagangotri, Mysuru, India 570006;3. Department of Physics, School of Sciences, Jain University (Deemed to be University), Bengaluru-560 011, India;4. Department of Biotechnology, Faculty of Natural Sciences, Adichunchanagiri University-Centre for Research and Innovation, BGSIT Campus, Adichunchanagiri University, B.G. Nagara, Mandya, India;5. Instituto Gulbenkian de Ciencia, R. Q.ta Grande 6, 2780-156 Oeiras, Portugal
Abstract:Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Many of these agents are hybrid molecules, which are designed through concept of molecular hybridization and have shown multiple pharmacological activities. This multifunctional attribute of these hybrid compounds makes them potential drug candidates for the treatment of multifactorial diseases such as cancer, Alzheimer’s disease, metabolic syndromes, AIDS, malaria, and cardiovascular diseases. The present review compiles research reports on development of different coumarin hybrids, classify these on the basis of their therapeutic uses and propose structure–activity relationships. It is intended to help medicinal chemist in designing and synthesizing novel and potent hybrid compounds for the treatment of different disorders.
Keywords:Coumarin  Anticancer  Antimicrobial  Antioxidant  Anti-inflammatory  Antiviral  MAO-B inhibitor  Hybrid
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