Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel |
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| Institution: | 1. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA;2. Johns Hopkins Ion Channel Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;3. Michigan State University, Department of Pharmacology & Toxicology, East Lansing, MI 48824, USA;4. Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA;5. Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;6. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA;7. Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA;8. Center for Chemical Genomics, University of Michigan, Ann Arbor, MI 48109, USA |
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| Abstract: | A novel series of substituted tetrahydropyrrolo3,4-c]pyrazoles were investigated as blockers of the N-type calcium channel (Cav2.2 channels), a chronic pain target. |
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| Keywords: | N-type calcium channel Pain |
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