The cannabinoid acids,analogs and endogenous counterparts |
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| Affiliation: | 1. Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea;2. Clinical Trial Center, Ajou University Hospital, Suwon, Republic of Korea;1. Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy;2. Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy;3. Dipartimento di Farmacia, Università di Napoli Federico II, Via Montesano 49, 80131 Napoli, Italy;4. Department of Plant Science, University of Pretoria, Pretoria 0002, South Africa |
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| Abstract: | The cannabinoid acids are a structurally heterogeneous group of compounds some of which are endogenous molecules and others that are metabolites of phytocannabinoids. The prototypic endogenous substance is N-arachidonoyl glycine (NAgly) that is closely related in structure to the cannabinoid agonist anandamide. The most studied phytocannabinoid is Δ9-THC-11-oic acid, the principal metabolite of Δ9-THC. Both types of acids have in common several biological actions such as low affinity for CB1 anti-inflammatory activity and analgesic properties. This suggests that there may be similarities in their mechanism of action, a point that is discussed in this review. Also presented are reports on analogs of the acids that provide opportunities for the development of novel therapeutic agents, such as ajulemic acid. |
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| Keywords: | Cannabinoid Ajulemic acid NAgly Lipoamino acid Prostaglandin Lipoxin |
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