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Enzymatic preparation of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines |
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| Affiliation: | 1. Department of Chemistry, University of Rochester, 120 Trustee Rd., Rochester, NY 14627-0216, New York, USA;1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia;2. S.N. Winogradsky Institute of Microbiology, Russian Academy of Sciences, Moscow 117312, Russia;2. Rigshospitalet, Copenhagen, Denmark;3. Mount Sinai Medical Center, New York, New York |
| Abstract: | The lipase catalyzed resolution of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines have been studied. For all the heterocycles, the best enantioselectivity was obtained using Candida antarctica lipases A and B as catalysts in hydrolytic processes. The absolute configuration of the optically pure obtained heterocycles has been assigned. |
| Keywords: | 3-amino-4-hydroxytetrahydrofuran 3-amino-4-hydroxypyrrolidine Heterocyclic amino alcohols Enzymatic resolution Biocatalysis |
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