Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1 |
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Affiliation: | 1. Department of Materials Physics and Chemistry, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People''s Republic of China;2. China Academy of Space Technology, Beijing 100094, People''s Republic of China;3. Department of Adult Joint Reconstruction, Beijing Jishuitan Hospital, Beijing 100035, People''s Republic of China;4. Department of Obsterics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, People''s Republic of China |
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Abstract: | The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), mediates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported. |
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Keywords: | Agonist Sphingosine-1-phosphate Difluorophosphonate Fluorine |
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