Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents |
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Institution: | 1. Department of Chemistry, Yuvaraja''s College, University of Mysore, Mysuru, Karnataka, India;2. Vidya Vikas Institute of Engineering and Technology, Mysuru, Karnataka, India;3. Department of Medical science, Community College-Abs, Yemen |
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Abstract: | A library of eighty-six assorted benzimidazole derivatives was screened for antiviral activity against a panel of ten RNA and DNA viruses.Fifty-two of them displayed different levels of activity against one or more viruses, among which CVB-5, RSV, BVDV and Sb-1 were the most frequently affected. In particular, fourteen compounds exhibited an EC50 in the range 9–17 μM (SI from 6 to >11) versus CVB-5, and seven compounds showed an EC50 in the range 5–15 μM (SI from 6.7 to ?20) against RSV, thus resulting comparable to or more potent than the respective reference drugs (NM108 and ribavirin). Most of these compounds derive from 2-benzylbenzimidazole, but also other molecular scaffolds as 1-phenylbenzimidazole (2), 2-trifluoromethylbenzimidazole (69), dihydropyrido3′,2′:4,5]imidazo1,2-a]1,4]benzodiazepin-5-one (3), dibenzoc,e]benzimidazo1,2-a]azepine (22), and 2-(tetrahydropyran-2-yl)benzimidazole (81, 82 and 86)] are related to interesting levels of activity against these or other viruses (BVDV, Sb-1). Thus, these scaffolds (some of which, so far unexplored), represent valid starting points to develop more efficient agents against pathologies caused by CVB-5, RSV, BVDV and Sb-1 viruses. |
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Keywords: | Benzimidazole derivatives RNA and DNA viruses Anti-CVB-5"} {"#name":"keyword" "$":{"id":"k0020"} "$$":[{"#name":"text" "_":"anti-RSV anti-Sb-1 activity |
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