C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: Retention of activity of highly lipophilic analogues against cancer cells |
| |
| Affiliation: | 1. Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA;2. Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium;3. Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant’Angelo, Via Cintia 4, 80126 Napoli, Italy;4. Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, Western Cape, South Africa;1. School of Electronics, Electrical Engineering and Computer Science, Queen''s University Belfast, Belfast BT9 5 BN, UK;2. IRIT, UPS-CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 09, France;1. School of Natural Sciences, Bangor University, Bangor LL57 2UW, UK;2. Chemical Analysis Facility, University of Reading, Reading RG6 6AD, UK;3. BioExtractions (Wales) Ltd., Unit 30, Tafarnaubach Industrial Estate, Tafarnaubach, Tredegar, Blaenau Gwent, NP22 3AA, UK;1. Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China;2. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;3. Department of Urology, Fujian Provincial Hospital, Fuzhou, China;4. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China;5. Okayama Medical Innovation Center, Okayama University, Okayama, Japan;1. Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 XueYuan Western Road, Wenzhou 325027, China;2. Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University,NanBai Xiang, Wenzhou 325000, China |
| |
| Abstract: | As a continuation of the studies aimed at the development of new anticancer agents derived from the Amaryllidaceae alkaloid lycorine, 35 C1,C2-ether analogues of this natural product were synthesized. The compounds were evaluated for antiproliferative activities in vitro in a panel of tumor cell lines with varied levels of apoptosis resistance. A strong correlation between the compound lipophilicity and anticancer activity was observed, indicating that cell permeability properties must be an important determinant in the design of lycorine-based anticancer agents. A theoretical docking model, consistent with the experimental observations, is presented. |
| |
| Keywords: | Cancer Apoptosis resistance Melanoma Glioblastoma Alkaloid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
