Kelsoenethiol and dikelsoenyl ether,two unique kelsoane-type sesquiterpenes,from the Formosan soft coral Nephthea erecta |
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| Affiliation: | 1. Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan;2. Department of Chemistry, Oakland University, Rochester, MI 48309, USA;3. Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan;4. Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;5. Center of Asia-Pacific Marine Researches, National Sun Yat-sen University, Kaohsiung, Taiwan;1. Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616 USA;2. Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0482, USA;3. Department of Microbiology & Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA;4. Quantum Electronics Department, Faculty of Physics, Vilnius University Sauletekio 10, LT10223 Vilnius, Lithuania;1. Necmeddin Erbakan University, Ahmet Kelesoglu Faculty of Education, Physics Education Dep., Konya, Turkey;2. Selcuk University, Science Faculty, Physics Department, Campus, Konya, Turkey;3. Selcuk University, Advanced Technology Research and Application Center, Campus, Konya, Turkey;1. GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, D-64291 Darmstadt, Germany;2. Frankfurt Institute for Advanced Studies FIAS, Ruth-Moufang-Str. 1, D-60438 Frankfurt am Main, Germany;3. Technische Universität Darmstadt, Karolinenplatz 5, D-64289 Darmstadt, Germany |
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| Abstract: | Two new kelsoane-type sesquiterpenes, namely kelsoenethiol (1) and dikelsoenyl ether (2), were obtained from the Formosan soft coral Nephthea erecta. Their structures were elucidated through extensive spectroscopic analyses, ESI orbitrap mass and quantum chemical calculations (QCC). The cytotoxicity against A-459 (human lung carcinoma), P-388 (mouse lymphocytic leukemia), and HT-29 (human colon adenocarcinoma) cancer cell lines of 1 and 2 was evaluated in vitro. Compound 1 showed cytotoxicity against P-388 and HT-29 cells with ED50s of 1.3 and 1.8 μg/mL, respectively. |
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| Keywords: | Kelsoane-type sesquiterpenes Quantum chemical calculations (QCC) Cytotoxicity |
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