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Halogenated diarylacetylenes repress c-myc expression in cancer cells
Affiliation:1. Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, United States;2. Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, United States;3. Center for Computational Drug Design, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, United States;4. Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0093, United States;5. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, United States;1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA;2. Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104, USA;1. Faculty of Chemistry, Department of Analytical Chemistry, University of Kashan, PO Box, Kashan 87317-51167, Iran;2. Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran;3. Department of Chemistry, Shahid Bahonar University of Kerman, PO Box, 76175-133 Kerman, Iran;4. Faculty of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran;1. Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan;2. SHI Accelerator Service Co. Ltd, 5-9-11 Kitashinagawa, Shinagawa-ku, Tokyo 141-8686, Japan;1. Faculty of Engineering & Science, Universiti Tunku Abdul Rahman, Jln Genting Klang, Setapak, Kuala Lumpur 53300, Malaysia;2. Faculty of Science, Universiti Tunku Abdul Rahman, Jln Universiti, Bandar Barat, Kampar 31900, Malaysia;3. Centre for Biodiversity Research, Universiti Tunku Abdul Rahman, Jln Universiti, Bandar Barat, Kampar 31900, Malaysia;4. Liquid Crystal Research Laboratory, School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia;5. Department of Materials Science & Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, China
Abstract:Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.
Keywords:Diarylacetylenes  Colon cancer  Antineoplastic agents  c-myc
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