The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments |
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| Institution: | 1. Department of Chemistry, Pennsylvania State University, University Park, PA 16802, United States;2. Department of Chemistry & Biochemistry, University of the Sciences, 600 S. 43rd Street, Philadelphia, PA 19104-4495, United States;1. Dept. of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK;1. Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France;2. Institut de Pharmacologie et de Biologie Structurale, CNRS and Université de Toulouse-Université Paul Sabatier, Equipe labellisée Ligue contre le Cancer, F-31077 Toulouse, France;1. State Key Laboratory of Microbial Metabolism, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People''s Republic of China;2. Scynexis, Inc., P.O. Box 12878, Research Triangle Park, NC 27709-2878, United States;1. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland;2. Faculty of Chemistry, Opole University, Oleska 48, 45-052 Opole, Poland;1. Anacor Pharmaceuticals, Inc., 1020 E. Meadow Circle, Palo Alto, CA 94303, USA;2. SCYNEXIS Inc., 3501 C Tricenter Boulevard, Durham, NC 27713, USA;1. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland;2. Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland;3. Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89b, 61-614 Poznań, Poland;4. Faculty of Chemistry, Opole University, Oleska 48, 45-052 Opole, Poland;5. NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Umultowska 85, 61-614 Poznań, Poland;1. TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA;2. Anacor Pharmaceuticals, Palo Alto, CA, USA;3. Texas A&M University, College Station, TX, USA |
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| Abstract: | Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles’ unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date. |
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| Keywords: | Benzoxaborole Oxaborole Benzoboroxole Sulfenic acid Boronic acid |
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