Design,synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs |
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Affiliation: | 1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar 522510 Andhra Pradesh, India;2. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh 522502, India;3. Department of Chemistry, Shree Velagapudi Ramakrishna Memorial College, Nagaram, Andhra Pradesh 522268, India |
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Abstract: | Several new benzofuran derivatives were synthesized, via appropriate synthetic route as anti-inflammatory agents. The anti-inflammatory activity of the prepared compounds was evaluated using carrageenan rat model. Among the synthesized compounds, some compounds showed comparable anti-inflammatory activity to nimesulide, the standard drug taken for anti-inflammatory studies. Docking study of the prepared compounds was performed for the study of interaction of molecules with the active site of COX-2. Preliminary biological studies and docking gave an interesting insight, into the validity of employing benzofuran analogues as good anti-inflammatory agent. |
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Keywords: | Benzofurans Inflammation Anti-inflammatory Drug design Molecular modeling |
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