Environmentally benign synthesis and antimicrobial study of novel chalcogenophosphates |
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| Institution: | 1. Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India;2. Department of Botany, Visva-Bharati (A Central University), Santiniketan 731235, India;1. Department of Chemistry, Johns Hopkins University, Baltimore, MD 21210, USA;2. GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA;3. Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA;1. Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India;2. Department of Microbial Biotechnology, Panjab University, Chandigarh, 160014, India;3. Department of Applied Sciences, University Institute of Engineering & Technology (U.I.E.T), Panjab University, Chandigarh, 160014, India;4. Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal;5. Department of Medical Sciences, iBiMED – Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal |
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| Abstract: | We report in this work an environmentally benign zinc mediated synthesis of aryl and benzyl phosphorochalcogenoates in ethanol within a short reaction time. In vitro antimicrobial study along with statistical analysis and seed germination assay were performed. These chalcogenophosphates possess strong antimicrobial activity against the reference strains. The antibacterial activity was determined against four standard strains (Bacilus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa). The antifungal activity was evaluated against one fungal strain Candida albicans. |
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| Keywords: | Chalcogenophosphate Green synthesis Antimicrobial activity Statistical analysis Seed germination assay |
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