Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities |
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| Institution: | 1. Analytical & Testing Center, Sichuan University, Chengdu 610064, China;2. Hangzhou Institute of Calibration and Testing for Quality and Technical Supervision, Hangzhou 310019, China;3. Wenzhou Entry–Exit Inspection and Quarantine Bureau of P.R.C, Wenzhou 325027, China;4. College of Chemistry, Sichuan University, Chengdu 610064, China |
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| Abstract: | Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1–6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range. |
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| Keywords: | Cucurbitane triterpenoids Cytotoxic activities |
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