Rat intestinal sucrase inhibition of constituents from the roots of Rosa rugosa Thunb. |
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Affiliation: | 1. Central Laboratory of Fujian Academy of Agricultural Sciences, Fujian 350003, China;2. State Key Laboratory Breeding Base of Marine Genetic Resource, Third Institute of Oceanography, SOA, Xiamen 361005, China;3. Collaborative Innovation Center of Deep Sea Biology, Hangzhou 310058, China;4. Inspection & Quarantine Technology Center, Xiamen Entry–exit Inspection and Quarantine Bureau (IQTC), Xiamen 361100, China;1. Department of Chemical and Biomedical Engineering, Florida State University, FAMU-FSU College of Engineering, 2525 Pottsdamer Street, Tallahassee, FL 32310, United States;2. Department of Biology and Marine Biology, University of North Carolina Wilmington, 601 South College Road, Wilmington, NC 28403-5915, United States |
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Abstract: | A new octanordammarane triterpene, 3β,15α-dihydroxymansumbinol (1) and a novel A-ring contracted oleanane triterpenoid, 2-formyl-(A)1–19α-hydroxy-1-norolean-2,12-dien-28-oic acid (2) were isolated from the roots extract of Rosa rugosa along with fifteen known compounds (3–17). Their structures were elucidated by extensive spectroscopic analysis, including 1D and 2D NMR, and FTICRMS. The MeOH extract, as well as CH2Cl2 and EtOAc fractions at a concentration of 0.5 mg/mL showed potent sucrase inhibitory activity, with inhibition percentage values of 84.67 ± 5.37%, 87.50 ± 2.78%, and 81.91 ± 2.90%, respectively. In addition, compounds 7–13 (1.0 mM) showed potent sucrase inhibitory activity (61.88 ± 3.19% to 84.70 ± 3.07% inhibition), which was comparable to that of the positive control, acarbose, with an inhibition percentage value of 50.96 ± 2.97%. Compounds 1, 2, 4, and 14–17 showed moderate and/or weak inhibitory activities at the same concentration. The α-glucosidase inhibitory activities of the extracts and purified compounds may provide a novel opportunity to develop a new class of antidiabetic agents. |
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Keywords: | Rosaceae Rosanol A Rusaic acid B A-ring contracted oleanane triterpenoid α-Glucosidase inhibition |
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