Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood |
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| Institution: | 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India;2. Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India;1. Toray Industries, Inc., Pharmaceutical Research Laboratories, 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan;2. Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan;1. Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;2. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA;4. Beijing Institute of Radiation Medicine, Beijing 100850, China;5. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan;1. Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran;2. Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China;1. University Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre Le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France;2. Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, Dr. J. Bignon, Dr. J. Dubois, avenue de la Terrasse, F-91198 Gif sur Yvette, France;1. Division of Endocrinology, Central Drug Research Institute (Council of Scientific and Industrial Research), Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India;2. Division of Medicinal & Process Chemistry, Central Drug Research Institute (Council of Scientific and Industrial Research), Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India |
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| Abstract: | The present study was undertaken to investigate and rationalize the in vitro antiosteoporotic activity of neoflavonoids, isolated from Dalbergia sissoo heartwood. Neoflavonoids were isolated using extensive column chromatography and identified as dalsissooal (1) a new compound and cearoin (2), dalbergin (3), 4-methoxy dalbergion (4), dalbergiphenol (5), dalbergichromene (6), methyl dalbergin (7) and latinone (8) as known compounds by comparison their spectroscopic data with those reported in the literature. Among the screened compounds, compounds 1, 3, 5–8 significantly increased proliferation as assessed by alkaline phosphatase activity and mineralization in calvarial osteoblast cells. |
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| Keywords: | Neoflavanoids Osteoporosis Osteoblast |
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