Natural hydrazine-containing compounds: Biosynthesis,isolation, biological activities and synthesis |
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| Affiliation: | 1. Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People’s Republic of China;2. College of Agriculture, Shanxi Agriculture University, Taigu 030801, Shanxi Province, People’s Republic of China;1. Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland;2. Department of Chemistry ‘G. Ciamician’, University of Bologna, via Selmi 2, 40126 Bologna, Italy;3. TriMen Chemicals Ltd, 92-318 Lodz, Poland;4. Scientia Advice, 20832 Desio (MB), Italy;5. Institute of Organic Chemistry, Lodz University of Technology, 90-924 Lodz, Poland;6. Institute of Biochemistry, Biological Research Centre of Hungarian Academy of Sciences, 6701 Szeged, Hungary;1. Dept. of Food Science and Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea;2. Dept. of Food and Nutrition, Daejeon Health Sciences College, Daejeon 300-711, Republic of Korea;1. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland;2. Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, 8B Jaczewskiego Street, 20-090 Lublin, Poland;3. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland;1. Plant Systems Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Daejeon, 34141, South Korea;2. Department of Environmental Biotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), 217 Gajeong-ro, Daejeon, 34113, South Korea;3. College of Pharmacy and Research Institute of Life Sciences, Gyeongsang National University, 501 Jinjudae-ro, Jinju, 52828, South Korea;4. Institute of Food Crops, Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, Jiangsu, China |
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| Abstract: | Hydrazine, hydrazone and hydrazide derivatives are nitrogen–nitrogen bond containing compounds. Such molecules are relatively scarce in nature and have been isolated from plants, marine organisms and microorganisms. These compounds exhibit remarkable structural diversity and relevant biological activities. The enzymes involved in the formation of the N–N bond are still unknown, but many lines of evidence support the involvement of N-nitrosation and N-hydroxylation activating steps. Beside the challenging N–N bond, N-acylases catalyzing the C–N bond formation contribute to the chemical diversity of N–N-containing natural products (N2NP). This review examines the state of knowledge regarding the biosynthesis of N2NP, for which only two biosynthetic gene clusters have been investigated. Biological properties and chemical synthesis of hydrazines, hydrazones and hydrazides are also reported. |
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| Keywords: | N–N bond synthesis and biosynthesis Hydrazine" },{" #name" :" keyword" ," $" :{" id" :" k0015" }," $$" :[{" #name" :" text" ," _" :" Hydrazone and hydrazide C–N bond biosynthesis Geralcins |
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