Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor |
| |
| Affiliation: | 1. Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA;2. Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;1. Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India;2. Academy of Scientific and Innovative Research (AcSIR), CSIR-IIIM, Jammu Campus, Jammu 180001, India;1. Hiroshima International University, Faculty of Clinical Nutrition, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan;2. Hiroshima International University, Faculty of Pharmaceutical Sciences, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan;3. National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan;4. Computer-aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya 663-8241, Japan;3. From the School of Life Sciences, University of Science and Technology of China, Hefei 230026, China,;4. the State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China,;5. the Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, and;6. Guangzhou Henovcom Biosciences Inc., Guangzhou 510530, China |
| |
| Abstract: | |
| |
| Keywords: | HTS" },{" #name" :" keyword" ," $" :{" id" :" k0010" }," $$" :[{" #name" :" text" ," _" :" high-throughput screen FXR" },{" #name" :" keyword" ," $" :{" id" :" k0020" }," $$" :[{" #name" :" text" ," _" :" farnesoid X receptor NRs" },{" #name" :" keyword" ," $" :{" id" :" k0030" }," $$" :[{" #name" :" text" ," _" :" nuclear receptors Cyp7A1" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" cytochrome 7A1 BAs" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" bile acids BSEP" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" bile salt export pump SAR" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" structure–activity relationship LBD" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" ligand-binding domain |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
