Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly |
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| Affiliation: | 1. Department of Chemistry, New York University, New York, NY 10003, USA;2. Nanometics LLC, 111 Great Neck Rd, Suite 212, Great Neck, NY 11021, USA;3. Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA;4. Department of Radiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA;1. Graduate School of System Informatics, Kobe University, 1-1, Rokkodai, Nada-ku, Kobe 657-8501, Japan;2. Institute of Industrial Science, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8505, Japan;3. Mizuho Information and Research Institute Inc., 2-3, Kanda Nishi-cho, Chiyoda-ku, Tokyo 101-8443, Japan;4. Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo University, 3-34-1, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan;1. Department of Chemistry, University of the Pacific, Stockton, CA 95211, USA;2. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;3. Departments of Chemistry and Physics, University of California, Berkeley, CA 94720, USA;1. Respiratory, Inflammation & Autoimmunity iMed, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden;2. Cardiovascular & Metabolic Diseases iMed, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden;1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russian Federation |
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| Abstract: | Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contained several fluorophores as the cargo for delivery and five hydrazine moieties as complimentary bio-orthogonal reactive sites. The system is designed to be flexible and allow for facile incorporation of a variety of targeting ligands. |
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| Keywords: | Cell surface self-assembly Targeted amplification Dendrimer |
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