Boseongazepines A–C,pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057 |
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| Institution: | 1. Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea;2. Department of Biomolecular Science, University of Science and Technology, 217 Gajunro, Yuseong-gu, Daejeon 305-333, Republic of Korea;3. World Class Institute Center, KRIBB, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 363-883, Republic of Korea;4. College of Pharmacy, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 570-749, Republic of Korea;5. Microbial Resources Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon 306-809, Republic of Korea;6. RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Hirosawa, Wako-shi, Saitama 351-0198, Japan;7. Chemical Biology Group, RIKEN CSRS, Hirosawa, Wako-shi, Saitama 351-0198, Japan;1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea;2. Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea;1. INQUINOA, CONICET, Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Lorenzo 456, T4000CAN Tucumán, Argentina;2. INQUINOA, CONICET, Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, T4000INI Tucumán, Argentina;3. Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata and Institute IFLP (CONICET, CCT-La Plata), C.C. 67, 1900 La Plata, Argentina |
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| Abstract: | Three new pyrrolobenzodiazepine derivatives, boseongazepines A–C (1–3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1–4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines. |
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| Keywords: | Pyrrolobenzodiazepine Streptomyces Cytotoxicity Boseongazepines |
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