Marine spongian sesquiterpene phenols,dictyoceratin-C and smenospondiol,display hypoxia-selective growth inhibition against cancer cells |
| |
| Institution: | 1. Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan;2. Department of Chemistry, Faculty of Science, Lampung University, Jl. Prof. Dr. Sumantri Brodjonegoro No. 1, Bandar Lampung 35145, Indonesia;1. Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea;2. Department of Chemistry, University of Iowa, Iowa City, USA;3. Department of Food and Medicine, International University of Korea, Jinju, Republic of Korea;4. Department of Food Science and Culinary, International University of Korea, Jinju, Republic of Korea;5. College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea;1. Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russian Federation;2. Far Eastern Federal University, Suhanova 8, Vladivostok 690950, Russian Federation;1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China;2. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany;1. Innovation Center of Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia;2. Institute for Biological Research “Siniša Stanković”, University of Belgrade, Despota Stefana 142, 11060 Belgrade, Serbia;3. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Center for Chemistry, Njegoševa 12, 11000 Belgrade, Serbia;4. Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia |
| |
| Abstract: | In the course of our search for hypoxia-selective growth inhibitors against cancer cells, a sesquiterpene phenol, dictyoceratin-C (1), was isolated from the Indonesian marine sponge of Dactylospongia elegans under the guidance of the constructed bioassay. Dictyoceratin-C (1) inhibited proliferation of human prostate cancer DU145 cells selectively under hypoxic condition in a dose-dependent manner at the concentrations ranging from 1.0 to 10 μM. The subsequent structure–activity relationship study using nine sesquiterpene phenol/quinones (2–10), which were isolated from marine sponge, was executed. We found that smenospondiol (2) also exhibited the similar hypoxia-selective growth inhibitory activity against DU145 cells, and the para-hydroxybenzoyl ester moiety would be important for hypoxia-selective growth inhibitory activity of 1. In addition, the mechanistic analysis of dictyoceratin-C (1) revealed that the 10 μM of 1 inhibited accumulation of Hypoxia-Inducible Factor-1α under hypoxic condition. |
| |
| Keywords: | Dictyoceratin-C Smenospondiol HIF-1α Hypoxia Cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
