Preparation and biodistribution of a 99mTc tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT |
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Affiliation: | 1. Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, No.12 jiangkang Road, Shijiazhuang 050011, China;2. Department of Tumor Imaging, The Fourth Hospital of Hebei Medical University, No.12 jiangkang Road, Shijiazhuang 050011, China |
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Abstract: | The deoxyglucose dithiocarbamate (DGDTC) was successfully labeled with the 99mTc(CO)3 core to provide the corresponding 99mTc(CO)3–DGDTC complex in good yields. The radiochemical purity of the 99mTc(CO)3–DGDTC complex was over 90%, as measured by high performance liquid chromatography (HPLC). The complex possessed good stability in saline at room temperature and in mouse plasma at 37 °C. Its partition coefficient result indicated that it was a hydrophilic complex. The electrophoresis results showed the complex was neutral. The biodistribution of 99mTc(CO)3–DGDTC in mice bearing S 180 tumor showed that the complex clearly accumulated in tumor, exhibiting high tumor/blood and tumor/muscle ratios and good tumor retention. Single photon emission computed tomography (SPECT) image studies showed there was a visible uptake in tumor sites, suggesting 99mTc(CO)3–DGDTC could be considered as a potential tumor imaging agent. |
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Keywords: | Tumor imaging agent Deoxyglucose Dithiocarbamate |
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