Thiophenes,polyacetylenes and terpenes from the aerial parts of Eclipata prostrata |
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| Affiliation: | 1. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People’s Republic of China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China;1. Oil & Gas Research Institute of the Russian Academy of Sciences, Gubkina 3 St, Moscow 119333, Russia;2. Gubkin Russian State University of Oil and Gas, Moscow 119333, Russia;3. Gazprom VNIIGAZ LLC, Moscow Region, Razvilka 142717, Russia;1. Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;2. College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;3. Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, and College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;4. Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam;1. Department of Food and Nutrition, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, Republic of Korea;2. Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea;3. Mokpo Marin Food-Industry Research Center, Mokpo 58621, Republic of Korea;4. College of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea;5. Department of Biotechnology, Dong-A University, Busan 49315, Republic of Korea;6. Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Republic of Korea;7. Department of Bakery & Barista, Suseong College, Daegu 42078, Republic of Korea;8. Suncheon Research Center for Natural Medicines, Suncheon 57922, Republic of Korea;1. College (Institute) of Integrative Medicine, Dalian Medical University, Dalian 116044, China;2. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;3. The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, Liaoning Province, China;4. Beijing University of Chinese Medicine, Beijing 100029, China;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey;2. Department of Pharmaceutical Chemistry, School of Pharmacy, Medipol University, 34083 Istanbul, Turkey;3. Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey |
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| Abstract: | One new bithiophenes, 5-(but-3-yne-1,2-diol)-5′-hydroxy-methyl-2,2′-bithiophene (2), two new polyacetylenic glucosides, 3-O-β-d-glucopyranosyloxy-1-hydroxy-4E,6E-tetradecene-8,10,12-triyne (8), (5E)-trideca-1,5-dien-7,9,11-triyne-3,4-diol-4-O-β-d-glucopyranoside (9), six new terpenoid glycosides, rel-(1S,2S,3S,4R,6R)-1,6-epoxy-menthane-2,3-diol-3-O-β-d-glucopyranoside (10), rel-(1S,2S,3S,4R,6R)-3-O-(6-O-caffeoyl-β-d-glucopyranosyl)-1,6-epoxy menthane-2,3-diol (11), (2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-β-d-glucopyranoside (12), 3β,16β,29-trihydroxy oleanane-12-ene-3-O-β-d-glucopyranoside (13), 3,28-di-O-β-d-glucopyranosyl-3β,16β-dihydroxy oleanane-12-ene-28-oleanlic acid (14), 3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl oleanlic-18-ene acid-28-O-β-d-glucopyranoside (15), along with fifteen known compounds (1, 3–7, and 16–24), were isolated from the aerial parts of Eclipta prostrata. Their structures were established by analysis of the spectroscopic data. The isolated compounds 1–9 were tested for activities against dipeptidyl peptidase IV (DPP-IV), compound 7 showed significant antihyperglycemic activities by inhibitory effects on DPP-IV in human plasma in vitro, with IC50 value of 0.51 μM. Compounds 10–24 were tested in vitro against NF-κB-luc 293 cell line induced by LPS. Compounds 12, 15, 16, 19, 21, and 23 exhibited moderate anti-inflammatory activities. |
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| Keywords: | Thiophene Polyacetylene Terpenoid glycosides Dipeptidyl peptidase IV Anti-inflammatory |
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