Biological evaluation of new antitumor taxoids: Alteration of substitution at the C-7 and C-10 of docetaxel期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Biological evaluation of new antitumor taxoids: Alteration of substitution at the C-7 and C-10 of docetaxel

Institution:	1. College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China;2. Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;1. Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Baojian Road 157, Nangang District, Harbin 150081, China;2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China;1. SANDOZ GmbH, Biochemiestraße 10, A-6250 Kundl/Tirol, Austria;2. Department of Molecular Biology, Division of Chemistry and Bioanalytics,University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria;1. Department of Physics, Periyar University, Salem 636011, Tamil Nadu, India;2. Department of Physics, Selvam Arts and Science College (Autonomous), Namakkal 637003, Tamil Nadu, India

Abstract:	A series of new docetaxol analogues have been designed and synthesized. And their cytotoxicities against cancer cells have been evaluated by MTT method. Most of these compounds showed selective inhibitions on human cancer cell lines. Among them, compound 8 exhibited higher inhibitory activity than Paclitaxel (Taxol) against several cancer cell lines. This work indicated that appropriate modification at C-7 and C-10 of docetaxel might be a promising approach for this unique class of anticancer compounds.

Keywords:	Paclitaxel Antitumor Analogues Biological assays Cabazitaxel
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