Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity |
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| Affiliation: | 1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China;2. Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;3. Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China;4. Protein Research Chair, Department of Biochemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia;5. Beijing Chao-Yang Hospital Affiliated with Beijing Capital Medical University, Beijing 100020, PR China;6. School of Life Sciences, Anhui University, Hefei 230601, PR China;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Department of Medicinal Chemistry and Pharmaceutical Analysis, Logistics College of Chinese People′s Armed Police Forces, Tianjin 300309, China;3. TaiJi Pharmaceutical Research Institute, Chongqing 400118, China;4. Guangdong Junyuan Pharmaceutical Co., Ltd., Guangzhou 525432, China;1. Department of Chemistry, Susquehanna University, 514 University Avenue Selinsgrove, PA 17870, United States;2. Math & Natural Sciences Department, Centenary College, Hackettstown, NJ 07840, United States;1. Biochemistry Unit, Department of Biological Science, Landmark University, Omu-Aran, Nigeria;2. Microbiology Unit, Department of Biological Science, Landmark University, Omu-Aran, Nigeria;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;2. Jining Medical University, Jining 272067, China;3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. State Key Laboratory of Quality Research in Chinse Medicine, University of Macau, Macau, China;3. Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA;1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People’s Republic of China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China |
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| Abstract: | The high mutation rate of RNA viruses has resulted in limitation of vaccine effectiveness and increased emergence of drug-resistant viruses. New effective antivirals are therefore needed to control of the highly mutative RNA viruses. The n-butanol fraction of the stem bark of Mangifera indica exhibited inhibitory activity against influenza neuraminidase (NA) and coxsackie virus 3C protease. Bioassay guided phytochemical study of M. indica stem bark afforded two new compounds including one benzophenone C-glycoside (4) and one xanthone dimer (7), together with eleven known compounds. The structures of these isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Anti-influenza and anti-coxsackie virus activities were evaluated by determining the inhibition of anti-influenza neuraminidase (NA) from pandemic A/RI/5+/1957 H2N2 influenza A virus and inhibition of coxsackie B3 virus 3C protease, respectively. The highest anti-influenza activity was observed for compounds 8 and 9 with IC50 values of 11.9 and 9.2 μM, respectively. Compounds 8 and 9 were even more potent against coxsackie B3 virus 3C protease, with IC50 values of 1.1 and 2.0 μM, respectively. Compounds 8 and 9 showed weak cytotoxic effect against human hepatocellular carcinoma and human epithelial carcinoma cell lines through MTT assay. |
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| Keywords: | Anacardiaceae Xanthones Mangiferin dimmer Gallotannins Neuraminidase inhibitors Coxsackie protease inhibitors Cytotoxic effect |
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