A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC? transporter |
| |
| Institution: | 1. Department of Radiation Oncology, RWTH Aachen University Hospital, Aachen, Germany;2. Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Germany;3. Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany;4. Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany;5. Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany;6. Jülich-Aachen Research Alliance (JARA) – Section JARA-Brain |
| |
| Abstract: | Oxidative stress has been implicated in a variety of conditions, including cancer, heart failure, diabetes, neurodegeneration and other diseases. A potential biomarker for oxidative stress is the cystine/glutamate transporter, system xC?. l-Aminosuberic acid (l-ASu) has been identified as a system xC? substrate. Here we report a facile method for 11C]N-Me labeling of l-ASu, automation of the radiochemical process, and preliminary PET imaging with EL4 tumor bearing mice. The results demonstrate uptake in the tumor above background, warranting further studies on the use of radiolabeled analogs of l-ASu as a PET imaging agent for system xC?. |
| |
| Keywords: | Radiolabelling C-11 Oxidative stress Cystine transporter N-methylation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
