Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia |
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| Institution: | 1. National Institute for Research in the Amazon (INPA), Av Andre Araújo 2936, CEP 69060-001, Manaus, Amazonas State, Brazil;2. Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av Bandeirantes 3900, CEP 14049-900, Ribeirão Preto, São Paulo State, Brazil;1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;2. Department of Pharmacy, Hainan General Hospital, Haikou 570311, PR China;3. Shenzhen Engineering Laboratory of Lingnan Medicinal Resources Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, PR China;1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2. Zhoukou Normal University, Zhoukou 466011, Henan, China;3. Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;4. Jiangxi Qingfeng Pharmaceutical Corporation, Ganzhou 341000, China;5. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6–15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa. |
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| Keywords: | Quassinoid Cytotoxicity A549 (human lung cancer cell) HeLa (human cervical cancer cell) |
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