Phragmalin-type limonoids with NF-κB inhibition from Chukrasia tabularis var. velutina |
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| Institution: | 1. Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China;2. Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China;3. Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China;4. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, PR China;5. Government Degree College at Amadala valasa, Srikakulam District, Andhra Pradesh 532185, India;1. Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan;2. Laboratory of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan;3. Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan |
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| Abstract: | Chemical investigation on Chukrasia tabularis var. velutina led to the identification of eight new phragmalin-type limonoids (1–8), as well as 20 known analogues. Compounds 1–4 are a rare class of C-15-acyl phragmalin-type limonoids, and particularly compounds 2–4 also possess a δ-lactone ring formed between C-16 and C-30. All the isolates were evaluated for inhibitory effects on NF-κB production, and four of which showed significant inhibitions. |
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| Keywords: | Phragmalin-type limonoids NF-κB inhibition |
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