|
|||||
|
|
Cytokine polymorphisms in silicosis and other pneumoconioses |
|
| Authors: | Yucesoy Berran Vallyathan Val Landsittel Douglas P Simeonova Petia Luster Michael I |
| Institution: | (1) Faculty of Pharmacy, Department of Toxicology, Ankara University, 06100 Ankara, Turkey;(2) Pathology and Physiology Research Branch, Health Effects and Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morganotown, WV 26505, USA;(3) Biostatistics Branch, Health Effects and Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morganotown, WV 26505, USA;(4) Toxicology and Molecular Biology Branch, Health Effects and Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morganotown, WV 26505, USA |
| Abstract: | Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor- (TNF-) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity. |
| Keywords: | silicosis pneumoconiosis cytokines polymorphism TNF- |
| 本文献已被 SpringerLink 等数据库收录！ | |