Alcohol, in a single pharmacological dose, decreases brain gangliosides |
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| Authors: | W R Klemm D M Foster |
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| Affiliation: | 1. Department of Veterinary Anatomy, Texas A&M University, College Station, TX 77843, USA;2. Laboratory Service, Olin E. Teague Veterans'' Administration Hospital, Temple, TX 76501, USA |
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| Abstract: | Alcohol penetrates into cell membranes, fluidizing and disordering the microenvironment. Here we report that associated with the disordering is a reduction of the normal level of brain gangliosides of adult male rats. The maximum decrement occurred in all major classes of gangliosides at 4 to 8 hours after a single pharmacological dose (3 gm/kg, IP). Because gangliosides have diverse, important functions in cell membranes, this effect of alcohol might be a basis for some of its intoxicating and addicting properties. |
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