Rigidity sensing explained by active matter theory |
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| Authors: | Marcq Philippe Yoshinaga Natsuhiko Prost Jacques |
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| Institution: | †Laboratoire Physico-Chimie Curie, Institut Curie/CNRS/Université Pierre et Marie Curie, Paris, France;‡Fukui Center for Fundamental Chemistry, Kyoto University, Kyoto, Japan;§ESPCI ParisTech, Paris, France |
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| Abstract: | The magnitude of traction forces exerted by living animal cells on their environment is a monotonically increasing and approximately sigmoidal function of the stiffness of the external medium. We rationalize this observation using active matter theory, and propose that adaptation to substrate rigidity results from an interplay between passive elasticity and active contractility. |
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