The Multiscale Systems Immunology project: software for cell-based immunological simulation |
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| Authors: | Faheem Mitha Timothy A Lucas Feng Feng Thomas B Kepler Cliburn Chan |
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| Institution: | (1) Center for Computational Immunology, Department of Biostatistics & Bioinformatics, Duke University Medical Center, 2424 Erwin Road, Hock Plaza Suite G06, Durham, NC 27705, USA;(2) Department of Immunology, and Department of Statistical Science, Duke University, Durham, NC 27705, USA |
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| Abstract: | Background Computer simulations are of increasing importance in modeling biological phenomena. Their purpose is to predict behavior and
guide future experiments. The aim of this project is to model the early immune response to vaccination by an agent based immune
response simulation that incorporates realistic biophysics and intracellular dynamics, and which is sufficiently flexible
to accurately model the multi-scale nature and complexity of the immune system, while maintaining the high performance critical
to scientific computing. |
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