The Expression Patterns of Nogo-A,Myelin Associated Glycoprotein and Oligodendrocyte Myelin Glycoprotein in the Retina After Ocular Hypertension |
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| Authors: | Xin-Xue Liao Dong Chen Jianbo Shi Yue-Qi Sun Shu-Juan Sun Kwok-Fai So Qing-Ling Fu |
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| Institution: | (1) Department of Cardiovasology, Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China;(2) Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China;(3) Department of Anatomy, The State Key Laboratory of Brain and Cognitive Sciences, and the Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;(4) Joint Laboratory for Brain Function and Health (BFAH), Jinan University and The University of Hong Kong, Guangzhou, 510632, Guangdong, China; |
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| Abstract: | Nogo-A, a major myelin inhibitory protein, inhibits axon growth and synaptic function in the central nervous system. Glaucoma
is a progressive neuropathy as a result of retinal ganglion cell (RGC) death. Synaptic degeneration is thought to be an early
pathology of neurodegeneration in glaucoma and precedes RGC loss. Here experimental ocular hypertension model was induced
in adult rats with laser coagulation of the episcleral and limbal veins. The expression of Nogo-A, myelin-associated glycoprotein
(MAG) and oligodendrocyte myelin glycoprotein (OMgp) in the retina was investigated using immunohistochemistry and Western
blotting. We found that Nogo-A was expressed in the RGCs and upregulated after the induction of ocular hypertension. OMgp
was only expressed in the inner plexiform layer. There was no MAG expression in the retina. Our data provided, for the first
time, the expression patterns of three myelin proteins in the adult retina and suggested an important role of Nogo-A in the
RGC death and synaptic degeneration in glaucoma. |
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