Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules |
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| Authors: | Dr. Roberto Tosi Nobuyuki Tanigaki Rosa Sorrentino Peter van Mourik Pavol Ivanyi |
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| Affiliation: | (1) Laboratory of Cell Biology, Via Romagnosi 18 A, 00196 Roma, Italy;(2) Department of Immunology Research, Roswell Park Memorial Institute, 14263 Buffalo, New York;(3) Gruppo di Microbiologia e Patologia Generale, Universitá di Roma, Italy;(4) Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinic Immunology, University of Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound. |
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