Increase in glutathione peroxidase activity in erythrocytes from trisomy 21 subjects. |
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| Authors: | P M Sinet A M Michelson A Bazin J Lejeune H Jerome |
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| Affiliation: | 1. Laboratoire de Biochimie Génétique, Institut de Progénèse, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75730 Paris, France;2. Institut de Biologie Physico-Chimique, Service de Biochimie-Physique, 13, rue P. et M. Curie, 75005 Paris, France |
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| Abstract: | Glutathione peroxidase activity has been measured in erythrocytes from normal subjects and from trisomy 21 patients. The latter cases show about 50 % increase of this enzyme similar to the increase observed for superoxide dismutase (erythrocuprein) suggesting either localisation of the gene for glutathione peroxidase on chromosome 21 (as is the case for erythrocuprein) or regulation of this enzyme by intracellular levels of O2, H2O2 or superoxide dismutase. |
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