Chemical and functional diversity of small molecule ligands for RNA |
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| Authors: | Hermann Thomas |
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| Institution: | Department of Computational Chemistry & Structure, Anadys Parmaceuticals, Inc., 9050 Camino Santa Fe, San Diego, CA 92121, USA. thermann@anadyspharma.com |
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| Abstract: | Functional RNAs such as ribosomal RNA and structured domains of mRNA are targets for small molecule ligands that can act as modulators of the RNA biological activity. Natural ligands for RNA display a bewildering structural and chemical complexity that has yet to be matched by synthetic RNA binders. Comparison of natural and artificial ligands for RNA may help to direct future approaches to design and synthesize potent novel scaffolds for specific recognition of RNA targets. |
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| Keywords: | antibiotics drug design ribosome RNA vitamins |
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