Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457 |
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| Authors: | Fa-Zuo Wang Zhi Huang Xue-Feng Shi Yu-Chan Chen Wei-Min Zhang Xin-Peng Tian Jie Li Si Zhang |
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| Institution: | 1. CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China;2. Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China |
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| Abstract: | Two new indole diketopiperazines, namely luteoalbusins A–B (1–2), along with eight known ones (3–10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1–5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. |
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