Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans |
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| Authors: | Narender Reddy Emmadi Krishnaiah Atmakur Ganesh Kumar Chityal Sujitha Pombala Jagadeesh Babu Nanubolu |
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| Institution: | 1. Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India;2. Chemical Biology Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India;3. Laboratory of X-ray crystallography, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India |
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| Abstract: | A series of fluorinated tetrahydropyrano3,2-c]chromenes and dihydropyrano3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa. |
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