New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells |
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| Authors: | Liqin Ding Feng Zhao Lixia Chen Zhihu Jiang Yue Liu Zhuomin Li Feng Qiu Xinsheng Yao |
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| Institution: | 1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;2. Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, People’s Republic of China;3. School of Pharmacy, Yantai University, Laishan District, Yantai 264005, People’s Republic of China |
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| Abstract: | Nine new monoterpene glycosides (1–9), together with 18 known compounds were obtained from the n-butanol soluble fraction of ethanol extract from Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectroscopic data. The inhibitory effects of these compounds (except compound 6) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated. Compounds 1, 21, 23, 25, and 27 showed strong inhibitory activity on NO production with IC50 values of 31.25, 36.13, 12.41, 6.87, and 41.94 μM, respectively. |
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