Design,synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands |
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| Authors: | Ramakrishna V.S. Nirogi Rajeshkumar Badange Ramasastri Kambhampati Anil Chindhe Amol D. Deshpande Vinaykumar Tiriveedhi Vishwottam Kandikere Nageswararao Muddana Renny Abraham Mukkanti Khagga |
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| Affiliation: | 1. Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India;2. Institute of Science and Technology, JNTU Hyderabad, Kukatpally, Hyderabad 500 085, India |
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| Abstract: | 4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives were designed and synthesized as 5-HT6 receptor (5-HT6R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities and activity in animal models of cognition. |
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