Viridin analogs derived from steroidal building blocks |
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Authors: | Kishore Viswanathan Sophia N. Ononye Harold D. Cooper M. Kyle Hadden Amy C. Anderson Dennis L. Wright |
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Affiliation: | Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States |
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Abstract: | Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex natural products from abundant steroid feedstock materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast cancer line. |
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