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Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases
Authors:Markus Hassler  Andreas G Ladurner
Institution:1. Department of Physiological Chemistry, LMU BioMedical Center, Faculty of Medicine, Ludwig Maximilians University of Munich, Butenandtstrasse 5B, 81377 Munich, Germany;2. European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany;3. Center for Integrated Protein Science Munich (CIPSM), Butenandtstrasse 5B, 81377 Munich, Germany;1. Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai 200030, China;2. Department of Physics and Astronomy, University of Missouri, Columbia, MO 65211, USA;3. Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871, China;4. Instituto de Astrofísica, Pontificia Universidad Católica de Chile, 306, Santiago 22, Chile;1. Cardiología/Electrofisiología, Wellington Regional Hospital, Victoria University School Of Medicine, Wellington, Nueva Zelanda;2. Programa de Especialización en Cardiología, Fundación Universitaria de Ciencias de la Salud, Servicio de Electrofisiología, Hospital Cardiovascular del Niño de Cundinamarca, Bogotá, Colombia;3. Electrofisiología, Fundación Santa Fe, Bogotá, Colombia;4. Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia;1. Servicio CES Cardiología, Medellín, Colombia;2. Universidad Nacional de Colombia, Bogotá, Colombia;3. Fundación Santafé de Bogotá, Bogotá, Colombia;4. Hospital Universitario Clínica San Rafael, Bogotá, Colombia
Abstract:
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  • Highlights? PARP1 recognizes DNA strand breaks through substrate-assisted dimerization. ? PARP1 ZFIII and WGR domains link DNA break recognition to enzyme activation. ? Tankyrase-dependent PARylation regulates Wnt signalling and Cherubism syndrome.
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