Chemotherapy of leishmaniasis. Part XI: Synthesis and bioevaluation of novel isoxazole containing heteroretinoid and its amide derivatives |
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| Authors: | SN Suryawanshi Avinash Tiwari Naveen Chandra Suman Gupta |
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| Institution: | 1. Division of Medicinal Chemistry, CSIR, Central Drug Research Institute, Lucknow 226001, India;2. Division of Parasitology, CSIR, Central Drug Research Institute, Lucknow 226001, India |
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| Abstract: | Novel isoxazole containing heteroretinoid (4) and its amide derivatives (5a–j) have been synthesized and evaluated for their in vivo antileishmanial activity against Leishmania donovani in hamsters. Compounds 3, 5a, 5d, 5k and 5l inhibited 70–76% parasite growth at 50 mg kg?1 × 5 days. The present study has helped us in identifying a new lead that could be exploited as a potential antileishmanial agent. |
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| Keywords: | Heteroretinoid Isoxazole In vivo trial Hamster |
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